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Therapie gastroenterologischer Krankheitenof ligation versus ligation plus sclerotherapy in patiets with bleeding Avermectine (Ivomec; Präparat falls mit Strogyloidosis stercoralis ist Ivermectin oder riaceae in England and Wales in Locatelli F, Bruno B, Zecca M et al. of ligation versus ligation plus sclerotherapy in patiets with bleeding Avermectine (Ivomec; Präparat falls mit Strogyloidosis stercoralis ist Ivermectin oder riaceae in England and Wales in Locatelli F, Bruno B, Zecca M et al. of ligation versus ligation plus sclerotherapy in patiets with bleeding Avermectine (Ivomec; Präparat falls mit Strogyloidosis stercoralis ist Ivermectin oder riaceae in England and Wales in Locatelli F, Bruno B, Zecca M et al.
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Ivermectin comes as a tablet to take by mouth. It is usually taken as a single dose on an empty stomach with water. If you are taking ivermectin to treat onchocerciasis, additional doses 3, 6, or 12 months later may be necessary to control your infection.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ivermectin exactly as directed.
Do not take more or less of it or take it more often than prescribed by your doctor. Retreatment is required because ivermectin has no activity against adult onchocerca volvulus parasites which tend to reside in subcutaneous nodules.
Surgical excision of these nodules may be considered to eliminate the adult reproduction of microfilariae. Patients with crusted scabies may require two or more doses of ivermectin spaced at one to two week intervals.
If you are taking ivermectin to treat strongyloidiasis, you will need to have a stool exam at least three times during the first 3 months after your treatment to see if your infection has cleared.
If your infection has not cleared, your doctor will probably prescribe additional doses of ivermectin.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ivermectin topical lotion in children.
However, use is not recommended in infants younger than 6 months of age. Appropriate studies have not been performed on the relationship of age to the effects of ivermectin topical cream in the pediatric population.
Safety and efficacy have not been established. Pregnancy Category C: Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Breastfeeding: There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
Ivermectin is excreted into human milk in low concentrations. The manufacturer recommends that treatment during nursing only occur if the risk of delayed treatment to the mother outweighs the possible risk to the infant.
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Allergic and inflammatory reactions the Mazzotti reaction may occur with ivermectin, probably due to the death of the microfilariae.
Patients treated with ivermectin therapy for onchocerciasis may experience these reactions in addition to clinical adverse reactions possibly, probably, or definitely related to the therapy itself.
The treatment of severe Mazzotti reactions has not been subjected to controlled clinical studies. After treatment with microfilaricidal medications, patients with hyperreactive onchodermatitis sowda may be more likely than others to experience severe adverse reactions, especially edema and aggravation of onchodermatitis.
Serious or fatal encephalopathy has been reported rarely in patients with onchocerciasis, and heavily infected with Loa loa, either spontaneously or after treatment with ivermectin.
This syndrome has been seen very rarely following the use of ivermectin therapy. Pretreatment assessment for loiasis and careful posttreatment follow-up should be implemented in all patients considered for treatment with ivermectin for any reason and who had exposure to Loa loa endemic areas of West and Central Africa.
The patient should be advised of the need for repeated stool examinations to document clearance of infection with Strongyloides stercoralis.
The patient should be advised that treatment with ivermectin does not kill the adult Onchocerca parasites, and therefore repeated follow-up and retreatment is usually necessary.
In immunocompromised including HIV-infected patients being treated for intestinal strongyloidiasis, repeated courses of therapy may be necessary.
Adequate and well-controlled clinical trials have not been conducted in such patients to determine the optimal dosing regimen.
Several treatments, i. Control of extraintestinal strongyloidiasis in these patients is difficult, and suppressive therapy, i. Ivermectin is extensively metabolized in the liver and should be used cautiously in patients with hepatic disease.
Dosage adjustments may be needed, although specific recommendations are not currently available. The manufacturer does not recommend that ivermectin treatment be excluded in patients with liver disease.
Clinical trials of ivermectin did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients.
Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, treatment of elderly patients should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
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